Prednisone is a synthetic corticosteroid (steroid) for oral use. It is used for suppressing the immune system and inflammation.
The synthetic corticosteroid Prednisone imitates the action of cortisol (hydrocortisone). This naturally-occurring corticosteroid is produced by the adrenal glands.
Prednisone has the profound anti-inflammatory effects and is used for the treatment of such diseases and conditions as arthritis, colitis, asthma, bronchitis, skin problems, and allergies.
The medicine Prednisone is activated in the body with the help of liver enzymes and is converted into prednisolone. In some people the medicine Prednisone remains ineffective because their liver function is impaired.
Prednisone is approved by the FDA for use in different diseases and conditions including: arthritis, blood disorders, breathing problems, severe allergies, skin diseases, cancer, eye problems, and immune system disorders.
The medicine is proven to decrease the immune system's response to a number of diseases and to diminish symptoms such as swelling and allergic-type reactions.
Doctors prescribe Prednisone for the following conditions:
Various types of arthritis;
Severe form of psoriasis;
Idiopathic thrombocytopenic purpura;
Autoimmune hemolytic anemia;
Corticosteroid Prednisone can suppress the immune system and prevent the body from rejecting transplanted organs.
Additionally this medicine can be prescribed as replacement therapy in patients whose adrenal glands cannot produce sufficient amounts of cortisol.
The dosage for Prednisone depends on the condition for which it is used. Besides, the age factor is also taken into consideration.
Oral medicine Prednisone should be taken with food to avoid stomach irritation. The dosage can start from 5 mg to 60 mg per day. The dosage can be changed during the treatment period if necessary.
It is common for this medicine to produce the necessary effect not immediately, but after several days of use. Usually 3-4 days or even more are needed to observe the results.
The discontinuation of the therapy is recommended to be gradual. The dosage should be lowered step by step to allow the adrenal gland to recover.
The abrupt discontinuation of Prednisone can result in corticosteroid insufficiency. The side effects of sudden stop in the therapy may include: nausea, vomiting, weakness, fatigue, decreased appetite, weight loss, diarrhea, abdominal pain.
Prednisone is a prescription medicine available with the doctor’s approval. A patient should take this medication only with a professional advice which will include the proper dosing, frequency of use, period of therapy.
The dosage and length of treatment with Prednisone are based on the medical condition and response to the treatment.
Before the treatment it is necessary to inform a doctor about medical conditions that a patient has, the medicines a patient uses. A medical history of fungal infections, heart problems, tuberculosis, herpes, hypertension, kidney or liver disease, other chronic or acute diseases should be reported to a doctor.
Interactions with other drugs may be possible with Prednisone. The medicines which can interact with Prednisone are NSAIDs, warfarin, ibuprofen, celecoxib, aspirin, clopidogel.