Application of the substance Valtrex
Shingles; infection of the skin and mucous membranes caused by the virus herpes simplex (including genital herpes); prevention of recurrence of diseases caused by herpes simplex virus.
Hypersensitivity (including to acyclovir), bone marrow transplantation, kidney transplantation (see "precautions").
Of renal dysfunction, clinically expressed form of HIV-infection, children up to age 12 years (safety and effectiveness not defined).
Application of pregnancy and breastfeeding
Pregnancy. Perhaps if the expected effect therapy outweighs the potential risk to the fetus (adequate and strictly controlled studies of safety in pregnant women is not conducted).
Clinically significant interactions in patients with normal renal function is not established. Cimetidine and probenecid (individually or together) after administration of Valtrex in single dose of 1000 mg increase Cmax and AUC and lower renal clearance of acyclovir. The pharmacokinetics of Valtrex is not changed while receiving digoxin, aluminum/magnesium antacids, thiazide diuretics.
Nefrotoksicnae drugs increase the risk of renal failure and disorders of the Central nervous system.
Symptoms: sedimentation of valtrex in the renal tubules.
Treatment: hemodialysis (acute renal failure and anuria).